By blocking these substances, ibuprofen reduces pain, lowers fever, and decreases swelling. An 800 milligram (mg) dose represents a high concentration, typically reserved for treating moderate to severe pain or chronic inflammatory conditions. Typical maximum doses of ibuprofen for adults and children ages 12 and older range from 1,200 mg (OTC ibuprofen) to 3,200 mg (prescription) per day. You’ll likely take ibuprofen 3 to 4 times a day (every 4 to 6 hours) to achieve this total daily dose. An ibuprofen overdose can damage your stomach or intestines. The maximum amount of ibuprofen for adults is 800 milligrams per dose or 3200 mg per day (4 maximum doses). How much ibuprofen can you take at once or in a day? Learn the safe dose limits, overdose signs, and when ibuprofen may raise stomach, kidney, or heart risks. Ibuprofen 800mg package insert / prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions and pharmacology. Understand the safety of taking 800mg of Ibuprofen daily. Explore potential health considerations and informed guidance for long-term use. However, you don't want to take more than 800 milligrams of ibuprofen unless it's directed by your doctor. Not only can taking more than the recommended dose of ibuprofen increase your risk of side effects, but too much ibuprofen can also cause seizures, low blood pressure, or coma.