What is Tylenol with Codeine 3? Tylenol with Codeine 3 is a combination medicine used to relieve moderate to severe pain. Tylenol with Codeine 3 may also be used for purposes not listed in this medication guide. Tylenol with Codeine (acetaminophen / codeine), also known as Tylenol 3, is a combination opioid medication. Both acetaminophen and codeine treat mild-to-moderate pain by blocking pain signals in the body. This combination medication is used to help relieve mild to moderate pain. It contains an opioid pain reliever (codeine) and a non-opioid pain reliever (acetaminophen). Codeine works in the brain to change how your body feels and responds to pain. Acetaminophen can also reduce a fever. What is acetaminophen and codeine? Acetaminophen and codeine is a combination medicine used to relieve moderate to severe pain. Acetaminophen and codeine may also be used for purposes not listed in this medication guide. Tylenol 3 is a prescription painkiller that combines acetaminophen with codeine. Learn its side effects, dosages, and risk of addiction and dependence. Medscape - Indication-specific dosing for Tylenol with Codeine, Tylenol 3, Tylenol 4 (codeine, acetaminophen), frequency-based adverse effects, comprehensive interactions. Acetaminophen and Codeine: learn about side effects, dosage, special precautions, and more on MedlinePlus Controlled Substance - Acetaminophen and codeine phosphate tablets contain codeine. Codeine in combination with acetaminophen, is a Schedule III controlled substance. Find patient medical information for Acetaminophen/Codeine (Tylenol with Codeine) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Acetaminophen and codeine combination oral solution or tablet can cause serious unwanted effects or fatal overdose if taken by children, pets, or adults who are not used to strong narcotic pain medicines.