Initiate treatment with acetaminophen and codeine phosphate tablets in a dosing range of 300 mg to 600 mg of acetaminophen and 30 mg to 60 mg of codeine phosphate every 4 hours as needed for pain, at the lowest dose necessary to achieve adequate analgesia. What is Tylenol with Codeine 3? Tylenol with Codeine 3 is a combination medicine used to relieve moderate to severe pain. Tylenol with Codeine 3 may also be used for purposes not listed in this medication guide. Find patient medical information for Acetaminophen/Codeine (Tylenol with Codeine) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Medscape - Indication-specific dosing for Tylenol with Codeine, Tylenol 3, Tylenol 4 (codeine, acetaminophen), frequency-based adverse effects, comprehensive interactions. Tylenol with Codeine (acetaminophen / codeine), also known as Tylenol 3, is a combination opioid medication. It's used for mild-to-moderate pain when other non-opioid therapies haven't worked well enough. ACETAMINOPHEN; CODEINE (a set a MEE noe fen; KOE deen) treats moderate pain. It is often prescribed when other medications have not worked well enough or cannot be tolerated. Codeine/Acetaminophen is a prescription medication used for the treatment of Mild to Moderately Severe Pain. Learn about side effects, drug interactions, dosages, warnings, and more. What is acetaminophen and codeine? Acetaminophen and codeine is a combination medicine used to relieve moderate to severe pain. Acetaminophen and codeine may also be used for purposes not listed in this medication guide. It contains an opioid pain reliever (codeine) and a non-opioid pain reliever (acetaminophen). Codeine works in the brain to change how your body feels and responds to pain. Acetaminophen and codeine combination oral solution or tablet can cause serious unwanted effects or fatal overdose if taken by children, pets, or adults who are not used to strong narcotic pain medicines.