Oxycodone acetaminophen is a prescription drug used for the management of moderate to severe pain. Learn about side effects, dosages, drug interactions, and more. Detailed Acetaminophen / Oxycodone dosage information for adults. Includes dosages for Pain; plus renal, liver and dialysis adjustments. Yes, oxycodone and acetaminophen are commonly taken together and have been combined in prescription medications for decades. In fact, some of the most widely prescribed pain medications, including Percocet, are pre-made combinations of these two drugs in a single tablet. Oxycodone and acetaminophen tablets are used to manage pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate, and when other pain treatments such as non-opioid pain medicines do not treat your pain well enough, or you cannot tolerate them. Oxycodone/acetaminophen is a combination pain -relief (analgesic) medication prescribed to treat acute moderate-to-severe pain. Oxycodone is an opioid analgesic, while acetaminophen is a nonopioid drug that reduces pain and fever. Oxycodone and acetaminophen combination can cause serious unwanted effects or fatal overdose if taken by children, pets, or adults who are not used to strong opioid pain medicines. Each oxycodone and acetaminophen tablet USP 5 mg/325 mg contains oxycodone hydrochloride 5 mg (equivalent to 4.4815 mg oxycodone) and acetaminophen 325 mg. It is available as a round, white scored tablet debossed with a 512 identification number. Find patient medical information for Oxycodone/Acetaminophen (Percocet, Tylox, and others) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user. When a patient who has been taking Oxycodone and Acetaminophen Tablets regularly and may be physically dependent no longer requires therapy with Oxycodone and Acetaminophen Tablets, use a gradual downward titration of the dosage to prevent signs and symptoms of withdrawal. The combination of Tylenol (acetaminophen) and oxycodone is frequently prescribed because acetaminophen can enhance the pain-relieving effects of oxycodone. This combination can be effective for managing pain when used correctly.