Ibuprofen is short-acting and is better suited for the treatment of acute pain, whereas Aleve is long-acting and is used for the treatment of chronic conditions. Aleve is more likely than ibuprofen to cause gastrointestinal (GI) side effects because it is longer acting. Aleve® Tablets temporarily reduce fever and relieve minor aches and pains due to arthritis, backaches, menstrual cramps, headaches, or toothaches. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve symptoms of arthritis (eg, osteoarthritis, rheumatoid arthritis, or juvenile arthritis) such as inflammation, swelling, stiffness, and joint pain. Tylenol (acetaminophen) helps reduce pain and fever but does not reduce inflammation. NSAIDs like Advil (ibuprofen) and Aleve (naproxen sodium) help reduce pain and inflammation, making them better for injuries. Side effects, including increased risk of stroke, occur with some NSAIDs. Tylenol vs. Advil vs. Aleve: Which Is Best? Learn about the differences between these popular OTC pain medications and which is best for headaches, fever, back pain and other conditions. Naproxen, sold under the brand name Aleve among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain, menstrual cramps, and inflammatory diseases such as rheumatoid arthritis, gout and fever. [7] Aleve is a non-steroidal anti-inflammatory drug (NSAID) that helps manage pain from headaches, arthritis, and other conditions. To safely use Aleve, take one pill every eight to 12 hours and no more than three pills in 24 hours. Overview: Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, reduce swelling, and lower fever. Common side effects include belly pain, upset stomach, heartburn, or. Aleve is a nonsteroidal anti-inflammatory drug (NSAID). Naproxen works by reducing hormones that cause inflammation and pain in the body. Aleve is used to temporarily relieve minor aches and pains due to arthritis, muscular aches, backache, menstrual cramps, headache, toothache,and the common cold. Aleve is also used to temporarily reduce fever. Aleve® is the only over-the-counter pain reliever that can give you up to 12 hours of pain relief brand with just one pill. The active ingredient in Aleve®, naproxen sodium, temporarily blocks the body’s production of prostaglandins, natural chemicals that have a direct role in pain.