Amitriptyline dosage varies depending on the condition being treated. For most adults, an initial dose is 75 mg per day, with the option to increase to 150 mg if needed. It may take up to 30 days to see the full effects. Learn how amitriptyline is dosed for depression, pain, sleep, and migraines. Understand safe use, maximum doses, and when to adjust treatment. Some hospitalized patients may need higher doses. Teenagers and Older adults—10 milligrams (mg) three times a day, and 20 mg at bedtime. Your doctor may adjust your dose as needed. Children younger than 12 years of age—Use and dose must be determined by your doctor. Carefully titrate dose of the antidepressant to the desired effect, including using the lowest feasible initial or maintenance dose, and monitor its response during coadministration with TCAs and. Detailed Amitriptyline dosage information for adults, the elderly and children. Includes dosages for Depression; plus renal, liver and dialysis adjustments. The recommended adult dosage for amitriptyline starts at 50 mg to 100 mg daily. Learn more about amitriptyline dosages, dose adjustments, and missed doses here. NHS medicines information on dosage for amitriptyline, how to take it and what to do if you miss a dose or take too much. Learn how amitriptyline works for nerve pain, what dose to expect, common side effects, and how it compares to gabapentin and duloxetine. Honest guide. Amitriptyline Dosage and Treatment Plan For neuropathic pain management, amitriptyline should be started at 10-25 mg at bedtime and gradually increased by 25 mg every 3-7 days as tolerated, with a maximum recommended dose of 150 mg per day. 1, 2 For depression, the average amitriptyline dosage range is 50 mg to 100 mg per day. For most pain conditions, it's 25 mg to 100 mg or 125 mg a day, while for fibromyalgia it's lower—10 mg to 50 mg a day.