Do not use amitriptyline if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. If you've been prescribed amitriptyline, you should be aware of possible drug interactions. We’ll talk about some of these interactions below, but it’s not a complete list. See the list of drugs that interact with Amitriptyline. Includes information on severity of interaction and the level of evidence for it. Amitriptyline interacts with various medications, including other antidepressants, pain medications, and more. Interactions can affect how amitriptyline works and cause or worsen side effects of amitriptyline. Does amitriptyline interact with my other drugs? Enter medications to view a detailed interaction report using our Drug Interaction Checker. Amitriptyline may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you or your caregiver notice any of these adverse effects, tell your doctor right away. 745 medications are known to interact with amitriptyline. Includes: drug, food, pregnancy, breastfeeding and therapeutic duplication warnings. Find patient medical information for Amitriptyline (Amitid, Elavil, Endep) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Use WebMD’s Drug Interaction Checker to identify potential interactions between medications, supplements, and foods. Reduce side effects and support safer treatment decisions. See documented drug interactions for Amitriptyline, grouped by severity with plain-language and clinical explanations and cited evidence.