Antithymocyte globulin is a purified concentrated globulin made from hyperimmune serum of horses immunized with human T lymphocytes. Antithymocyte globulin is used in renal transplant patients as an adjunct therapy in the treatment of graft rejection. What is Anti-Thymocyte Globulin (ATG)? Anti-Thymocyte Globulin (ATG) is a drug made of antibodies that suppress the immune system. ATG is made by injecting horses with white blood cells from humans, called lymphocytes. Anti-thymocyte globulin (rabbit) can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. What is anti-thymocyte globulin (rabbit)? Anti-thymocyte globulin is a sterilized solution made of the cells of rabbits that have been injected with white blood cells from humans. Anti-thymocyte globulin lowers your body's immune system. The immune system helps your body fight infections. Antithymocyte Globulin (Rabbit) reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI). THYMOGLOBULIN ® (anti-thymocyte globulin [rabbit]) is a purified, pasteurized, immunoglobulin G, obtained by immunization of rabbits with human thymocytes. This immunosuppressive product contains cytotoxic antibodies directed against antigens expressed on human T-lymphocytes. Anti-thymocyte globulin (ATG) is an infusion of horse, bovine or rabbit-derived antibodies against human T cells and their precursors (thymocytes), which is used in the prevention and treatment of acute rejection in organ transplantation and therapy of aplastic anemia due to bone marrow insufficiency. Anti-thymocyte globulin (rabbit) injection is used to prevent and treat rejection of kidney transplants. Anti-thymocyte globulin (rabbit) injection is in a class of medications called polyclonal antibodies. Product approval information is indicated for the prophylaxis and treatment of acute rejection in patients receiving a kidney transplant. Use in conjunction with concomitant immunosuppression. Anti-thymocyte globulin (ATG) is a polyclonal IgG component prepared and collected from the serum of various animals (rabbit, horse, goat or pig) that have been immunized against human thymocytes or other lymphocytes.