Baclofen, sold under the brand name Lioresal among others, is a central nervous system (CNS) depressant and derivative of the inhibitory neurotransmitter, gamma -Aminobutyric acid (GABA). NHS information about the medicine baclofen, including what it's used for, who can take it, how to take it and side effects. Baclofen is a muscle relaxer. It's used to treat muscle spasms from multiple sclerosis or spinal cord injuries in adults and children ages 12 years and older. This medication is taken by mouth, typically 3 times a day. Learn about the side effects of baclofen, from common to rare, for consumers and healthcare professionals. View baclofen information, including dose, uses, side-effects, renal impairment, pregnancy, breast feeding, contra-indications and important safety information. Find patient medical information for Baclofen (Lioresal, Fleqsuvy, and others) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Baclofen is used to help relax certain muscles in your body. It relieves the spasms, cramping, and tightness of muscles caused by medical problems, including multiple sclerosis or certain injuries to the spine. Baclofen is a muscle relaxant used to treat spasticity and muscle pain in conditions like multiple sclerosis and spinal cord injuries by easing nerve signals. Baclofen is in a class of medications called skeletal muscle relaxants. Baclofen acts on the spinal cord nerves and decreases the number and severity of muscle spasms caused by multiple sclerosis or spinal cord conditions. It also relieves pain and improves muscle movement. Baclofen is a muscle relaxant and antispastic used for treating spasm of skeletal muscles, muscle clonus, rigidity, and pain caused by multiple sclerosis. Baclofen is also injected into the spinal cord to treat severe spasticity, spinal cord injuries, and other spinal cord diseases.