New Dosing Interval and Schedule for the Bexsero MenB-4C Vaccine: Updated Recommendations of the Advisory Committee on Immunization Practices - United States, October 2024. Find dosing information for BEXSERO (Meningococcal Group B Vaccine) for every eligible patient regardless of risk level. 1 dose required in the 2nd year of life, after an interval of ≥2 months from the last dose.† For patients looking for more rapid protection, such as those about to leave for college, clinicians can choose to use a three-dose series of Bexsero or Trumenba (interval of zero, one to two months, and six months). How many doses are required? Babies receive three doses: at 2 and 3 months* and a booster at 12 months of age. Anyone receiving the vaccine over the age of 2 years only requires 2 doses. It is vital that all doses are given, as protection following one dose is limited. The two brands of MenB vaccines are not interchangeable. The series, and booster doses when indicated, must be started and completed with the same brand of vaccine.1 Two-dose schedule: Administer a dose (0.5 mL) at 0 and 6 months. If the second dose is administered earlier than 6 months after the first dose, a third dose should be administered at least 4 months after the second dose. ACIP recommends MenB-FHbp vaccine as a 2-dose series (at intervals of 0 and 6 months) for adolescents and young adults and a 3-dose series (at 0, 1–2, and 6 months) for those at increased risk. Updated label introduces a 2-dose primary series starting at 2 months with a booster dose at 12-15 months, and with at least a 6-month interval between the primary series and booster dose 1,a. Only BEXSERO offers a 2-dose vaccination series with 1-month interval between the first and second dose 1,2,b. On October 24, 2024, the Advisory Committee on Immunization Practices (ACIP) updated its recommendations for MenB-4C to align the dosing interval and schedule with the new Food and Drug Administration (FDA) label and harmonize with recommendations for MenB-FHbp (Trumenba, Pfizer, Inc.) vaccine.