Get relief from minor pain and skin itching caused by most outdoor itches with Benadryl Extra Strength Itch Stopping Anti-Itch Cream. Get relief from minor pain and skin itching caused by most outdoor itches with Benadryl Extra Strength Itch Stopping Anti-Itch Cream. It works by blocking the effects of a certain natural substance (histamine) that causes itching. This product may also contain other ingredients (skin protectants such as allantoin, zinc acetate) that may help relieve symptoms such as dry skin, weeping, or oozing. Get relief from minor pain and skin itching caused by most outdoor itches with Benadryl Extra Strength Itch Stopping Anti-Itch Cream. Get relief from minor pain and skin itching caused by most outdoor itches with Benadryl Extra Strength Itch Stopping Anti-Itch Cream. Get relief from minor pain and skin itching caused by most outdoor itches with Benadryl Extra Strength Itch Stopping Anti-Itch Cream. Itchy skin relief: should you reach for Benadryl cream or hydrocortisone? GoodRx compares the two creams to help you choose the best treatment for fast relief. Easy-to-read patient leaflet for Benadryl Itch Stopping. Includes indications, proper use, special instructions, precautions, and possible side effects. Get extra strength itch relief from BENADRYL ® with this cooling anti-itch topical analgesic cream for itchy skin, rash, and bug bites. Made with 2% diphenhydramine hydrochloride, a topical analgesic pain reliever, and 0.1% zinc acetate skin protectant, this topical cream temporarily relieves itching associated with insect bites, sunburn, scrapes, minor skin irritations, burns, cuts, and rashes due to poison ivy, oak and sumac.