In a medical context, “buccal” is a directional term meaning pertaining to or directed toward the cheek. It describes the tissues and structures adjacent to the inner lining of the cheek, such as the buccal mucosa (the moist mucous membrane lining the inside of the cheek). Define buccal. buccal synonyms, buccal pronunciation, buccal translation, English dictionary definition of buccal. adj. Of or relating to the cheeks or the mouth cavity. buc′cal·ly adv. American Heritage® Dictionary of the English Language, Fifth Edition. Buccal administration is a topical route of administration by which particular drugs held or applied in the buccal (/ ˈbʌkəl /) area (in the cheek) will diffuse through the oral mucosa — (tissues that line the mouth) — and will thereby enter directly into the bloodstream. buccal relating to the mouth cavity. For example, buccal epithelium lines the inside of the cheeks. Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005 BUCCAL definition: 1. relating to the inside of the mouth, especially the cheek 2. relating to the inside of the…. Learn more. The meaning of BUCCAL is of, relating to, near, involving, or supplying a cheek. How to use buccal in a sentence. of or relating to or toward the cheek adjective oriented toward the inside of the cheek “the buccal aspect of the gum” synonyms: oral of or involving the mouth or mouth region or the surface on which the mouth is located The buccal surface is the surface of a tooth that faces the cheek. The labial surface refers to the front surface of anterior teeth, while the buccal surface refers to the outer surface of posterior teeth facing the cheek. Buccal is a technical anatomical term used in the context of medicine. When it means located in the mouth, buccal is synonymous with oral, which is a much more common term. BUCCAL meaning: 1. relating to the inside of the mouth, especially the cheek 2. relating to the inside of the…. Learn more.