How Much Benadryl Can I Give My Dog? The standard Benadryl dosage for dogs is 1 mg of Benadryl per pound of body weight, given 2 to 3 times daily (every 8–12 hours). Most veterinarians follow this guideline when recommending over-the-counter dog antihistamines like Benadryl for pets experiencing allergies, itching, insect bites, or mild. Benadryl is one medication in our drug cabinet that can be given to dogs, but it’s imperative to know how, why, and how much of this medication can be given, or it can cause more problems than it solves. For our canine companions, Benadryl can be useful for treating mild allergies, anxiety, and travel sickness. Learn about Benadryl for dogs, including how much you can give your dog and if it's safe, with expert insights from a veterinarian. Your vet can advise how much Benadryl to give your dog or suggest other treatment options for managing allergies or anxiety. Learn about Benadryl for dogs, including how much you can give your dog, what it treats, and possible side effects, with expert insights from a veterinarian. How much Benadryl can I give my dog? Both the appropriate dosage and the practical dose of Benadryl must be accurately calculated based on your dog's weight, and consulting your veterinarian is the only way to establish the safest individual dose. How much Benadryl can you give your pup? Our handy Benadryl dosage chart for dogs by weight can tell you what's safe. Benadryl is a human medication that can be used in dogs to relieve allergy symptoms. But you have to be sure you're giving the right dose for your dog's size. (Photo Credit: E+/Getty Images) Find the safe Benadryl dosage for dogs by weight, how often to give it, which formulas to avoid, and when it simply won't help. If you are considering using Benadryl for your dog, this guide should be helpful. It reviews how Benadryl works, dosing and side effects.