If you've recently started taking sertraline and find yourself feeling unusually tired, you're not alone. Fatigue is a common side effect of this medication, and it can be frustrating to deal with, especially when you're seeking relief from other symptoms. In this article, we'll explore the possible causes of sertraline-induced fatigue, discuss its connection with the medication, and provide. Zoloft starts working in 2 to 6 weeks. You might see changes in sleep and energy levels in just 1 to 2 weeks. Still, side effects could make some stop taking it within the first three months. Remember, your body usually adjusts after the first couple of weeks. Common Zoloft side effects include: Headache Nausea Fatigue Dry mouth Sleep disturbances Less common, yet serious side effects can be. Sertraline can make you feel tired or affect your thinking and reaction time. Do not drive or do other activities that require alertness and coordination until you know how sertraline affects you. Can Zoloft make you sleepy during the day? Yes, Zoloft can make some people feel sleepy or sluggish during the day, especially in the first few weeks of treatment. This is a common Zoloft side effect and is usually temporary. Taking Zoloft for anxiety may relax the nervous system, which can result in daytime tiredness for some individuals. Sertraline (Zoloft) is an antidepressant that can cause various side effects, such as nausea, dry mouth, and diarrhea. Sleep changes are also possible. These side effects often improve after you’ve been taking sertraline for a few weeks. Other sertraline side effects include weight changes and sexual side effects. They aren’t as common, but they generally don’t improve with time. Rare. A common side effect associated with Zoloft (sertraline) is sleepiness and insomnia. It is thought that the change in the level of serotonin, a chemical that regulates your sleep in your body, is one of the reasons why people often experience this side effect. Sertraline can make some people feel sleepy due to its effects on chemicals in the brain, especially in the first days to weeks of treatment. Others experience the opposite problem and develop insomnia instead. Clinical trials suggest that drowsiness, fatigue, and other sleep-related side effects are common, but they are usually mild and often improve as the body adapts to the medication over. Zoloft is a common antidepressant, but there are some side effects you should be aware of, like minor weight gain, headaches, and sleep and sex drive changes. Taking Zoloft alongside anything else that causes sedation, including over-the-counter antihistamines, sleep aids, or alcohol, can make the drowsiness significantly worse and longer-lasting. Age is another factor: older adults tend to metabolize medications more slowly and may notice sedation that takes longer to resolve. 87 votes, 89 comments. Is anyone exhausted on sertraline/zoloft? I swear I’m just as tired after sleeping 9 hours as I am after sleeping 3. I feel….