Yes, Zoloft can make some people feel sleepy or sluggish during the day, especially in the first few weeks of treatment. This is a common Zoloft side effect and is usually temporary. A common side effect associated with Zoloft (sertraline) is sleepiness and insomnia. It is thought that the change in the level of serotonin, a chemical that regulates your sleep in your body, is one of the reasons why people often experience this side effect. About 13% of people taking Zoloft in clinical trials reported drowsiness, compared to 7% on placebo, so while it’s a common side effect, most people on the drug don’t experience it at all. Sertraline can make some people feel sleepy due to its effects on chemicals in the brain, especially in the first days to weeks of treatment. Others experience the opposite problem and develop insomnia instead. Sertraline can make you feel tired or affect your thinking and reaction time. Do not drive or do other activities that require alertness and coordination until you know how sertraline affects you. Antidepressants slow your nervous system down, so one isn't sensitive to everything. It can make you sleepy and not want to do anything. Once your blood levels adjust, which usually takes a good 30 days, your body will feel better and you have your energy level back. Hang in there and keep us posted! I can relate – being constantly tired on sertraline can be quite challenging. You might consider discussing this with your doctor to explore alternatives or strategies to manage the sleepiness. If you've recently started taking sertraline and find yourself feeling unusually tired, you're not alone. Fatigue is a common side effect of this medication, and it can be frustrating to deal with, especially when you're seeking relief from other symptoms. Common side effects of Zoloft include diarrhea, nausea, trouble sleeping or sleepiness, dry mouth, tremors, and sexual side effects like erectile dysfunction or difficulty reaching orgasm. Most. Key takeaways: Common sertraline (Zoloft) side effects include nausea, dry mouth, and diarrhea. Sleep changes are also possible. These side effects often improve after you’ve been taking sertraline for a few weeks. Other sertraline side effects include weight changes and sexual side effects.