What are the differences between Zoloft and Celexa? Zoloft (sertraline) and Celexa (citalopram hydrobromide) are antidepressants called selective serotonin reuptake inhibitors (SSRIs) prescribed to treat depression. Celexa and Zoloft have similar drug interactions and side effects. But they still have differences. These nuances can help you decide if either medication is right for you. Celexa (citalopram) and Zoloft (sertraline) are first-choice treatment options for depression, among other health conditions. Celexa (citalopram) and Zoloft (sertraline) are both SSRIs used to treat mood disorders like major depressive disorder and PTSD. While they function similarly by increasing serotonin levels, differences exist in their specific uses, side effects, and dosing. 1 2 Compare Celexa vs Zoloft head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Celexa and Zoloft treat depression but work in different ways. Compare the side effects and cost to find out which one is better. Celexa vs Zoloft: A side-by-side comparison This table breaks down the main differences between Celexa and Zoloft to help you understand how each medication might fit your specific situation. Celexa vs Zoloft explained. Compare benefits, side effects, and uses with expert insights from MRSC Solutions. Compare Zoloft and Celexa side effects, costs and risks for treating Depression. Zoloft (sertraline) and Celexa (citalopram hydrobromide) are a type of antidepressant called a selective serotonin reuptake inhibitor (SSRI) prescribed for the treatment of depression. Zoloft and Celexa are antidepressants used to treat depression and other mental health conditions. However, prescribers may recommend one medication over the other based on the drug’s effectiveness in treating the health condition and the medications that someone has tried before.