What side effects may I notice from receiving this medication? Side effects that you should report to your care team as soon as possible: Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat Esophageal ulcer—loss of appetite, throat pain, pain or trouble swallowing, heartburn, nausea, vomiting, dry cough What are the most common side effects of clindamycin? The most common side effects of clindamycin are listed below. Tell your health care provider if you have any of these side. Clindamycin (Cleocin) is used to treat serious infections caused by bacteria. Includes clindamycin side effects, interactions, and indications. Common side effects of clindamycin include abdominal pain, nausea, vomiting, diarrhea, skin reactions, jaundice, abnormal liver function test results, and others. Use clindamycin during pregnancy only if clearly needed. Avoid use when breastfeeding if possible. Learn about the side effects of clindamycin, from common to rare, for consumers and healthcare professionals. Learn about the common and rare side effects of oral clindamycin, including how to manage them and when to seek medical care. Clindamycin is a drug in the treatment of serious bacterial infections. Learn about side effects, drug interactions, dosages, warnings, and more. This guide explains six of the most common and serious Clindamycin side effects and how to handle them. Many people experience mild gastrointestinal symptoms such as nausea, vomiting, or stomach discomfort while taking Clindamycin. The most common side effects of clindamycin are feeling sick (nausea), being sick (vomiting), and tummy (stomach) discomfort. If you develop diarrhoea while you are taking clindamycin, you must contact your doctor for advice before you take any more doses. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.