If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco. This article describes the dosages of Cymbalta, as well as its strengths and how to take it. To learn more about Cymbalta, see this in-depth article. Consider starting at 30 mg qDay for 1 week to allow for therapy adjustment before increasing to 60 mg qDay. Target dosage: 60 mg/day PO; not to exceed 120 mg/day. There is no evidence that doses. Cymbalta (duloxetine) is prescribed for anxiety, depression, fibromyalgia, and certain types of pain. Learn about its dosages, form, strengths, and more. For adults younger than age 65 years, the recommended dosage is 60 mg once per day. Most people can start with this dosage. Sometimes, your doctor may prescribe a starting dosage of 30 mg. Detailed dosage guidelines and administration information for Cymbalta (duloxetine hydrochloride). Includes dose adjustments, warnings and precautions. Here’s a review of the recommended Cymbalta dosages for each condition it’s approved to treat. Keep in mind that your prescriber may suggest a different dose based on your personal medical history.