Cymbalta (duloxetine) is used to treat major depressive disorder, general anxiety disorder and fibromyalgia. Includes Cymbalta side effects, interactions and indications. Cymbalta should not be prescribed to patients with substantial alcohol use or evidence of chronic liver disease (5.2). • Orthostatic Hypotension and Syncope: Cases have been reported with duloxetine therapy (5.3). Serious side effects are less common. They include suicidal thoughts in young people, liver damage, serotonin syndrome, fainting and falls, bleeding, severe skin reactions, and low sodium levels in the blood. Stopping duloxetine suddenly can also cause withdrawal symptoms such as dizziness and nausea. Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem. Duloxetine may cause a serious condition called serotonin syndrome if taken together with some medicines. Cymbalta has a low risk of liver damage but can cause serious liver injury in rare cases, especially with pre-existing liver conditions. Yes, duloxetine can cause elevated liver enzymes and carries a risk of hepatotoxicity, ranging from mild asymptomatic transaminase elevations to rare cases o. Cymbalta, known generically as duloxetine, is a medication prescribed to treat conditions such as depression and neuropathic pain; however, physicians and patients must be aware of the potential for drug-induced liver injury. The medication's effects on hepatic function may lead to elevated liver enzymes, signaling possible liver damage. Monitoring liver function tests regularly becomes. Selective serotonin reuptake inhibitors (SSRIs) with a lower risk of liver injury include fluoxetine, paroxetine, citalopram, and escitalopram. One concern when using SSRI in patients with liver disease is its association with GI bleeding, and the extent of risk of bleeding in those with liver disease. Liver Damage Associated with Cymbalta (Duloxetine) Cymbalta (duloxetine) has been reported to cause liver damage in some patients, although the incidence is rare 3, 4, 5. Elevations in liver enzymes have been observed in a small fraction of patients treated with duloxetine, which generally resolve spontaneously without any change in treatment 3. Cymbalta is a depression and anxiety medication. Here are 13 side effects to know before taking Cymbalta and when to consult your prescriber.