The medication's effects on hepatic function may lead to elevated liver enzymes, signaling possible liver damage. Monitoring liver function tests regularly becomes essential when initiating and continuing Cymbalta to mitigate the risks associated with its use. Serious side effects with Cymbalta are less common but require urgent medical care. Liver damage Cymbalta can cause severe liver problems, including hepatitis and liver failure. This risk is higher if you drink large amounts of alcohol. Symptoms may include: Yellowing of your skin or eyes (jaundice) Dark urine Severe pain in the upper right. Cymbalta (duloxetine) can cause liver damage, and patients should be closely monitored for signs of liver dysfunction, particularly during the first few months of treatment. Hepatotoxicity: Hepatic failure, sometimes fatal, has been reported in patients treated with Cymbalta. Cymbalta should be discontinued in patients who develop jaundice or other evidence of. Cymbalta impacts various systems, including blood pressure, heart rate, and liver function. Some people experience rapid heartbeat, shortness of breath, gastrointestinal bleeding, and orthostatic hypotension (a sudden drop in blood pressure upon standing). Yes, duloxetine can cause elevated liver enzymes and carries a risk of hepatotoxicity, ranging from mild asymptomatic transaminase elevations to rare cases of severe liver injury including hepatic failure. 1 Cymbalta has a low risk of causing liver damage but can lead to serious liver injury in rare cases. Most patients tolerate it well, especially when taken as prescribed and without pre-existing liver conditions. Duloxetine-induced liver injury in patients with preexisting liver disease or chronic alcohol use is known. However, we have found that duloxetine can also induce liver injury in cases without those risk factors. Many Cymbalta side effects improve over time as your body gets used to the medication. But if they don’t, your prescriber may adjust your dosage or recommend a different antidepressant. While rare, serious Cymbalta side effects can happen. Examples include serotonin syndrome and liver damage. Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem. Duloxetine may cause a serious condition called serotonin syndrome if taken together with some medicines.