Cymbalta (duloxetine) can cause side effects that range from mild daily nuisances to much more serious health issues. The most common Cymbalta side effects include nausea, dry mouth, sleepiness, fatigue, constipation, loss of appetite, increased sweating, and dizziness. Below, we’ll explain everything you need to know by covering the common, serious, and long-term side effects, how to manage them, and what to watch for if you decide to stop taking Cymbalta. Common Cymbalta side effects include nausea, fatigue, changes in sleep, and sexual dysfunction. Serious side effects require medical attention such as a risk of suicidal thoughts, symptoms of mania, and allergic reactions. What are the most common side effects of duloxetine? The most common side effects of duloxetine are listed below. Tell your healthcare provider if you have any of these side effects that. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Common side effects of Cymbalta include: nausea, dry mouth, constipation, diarrhea, fatigue, tired feeling, drowsiness, difficulty sleeping, loss of appetite, and dizziness. Some patients may experience withdrawal reactions such anxiety, nausea, nervousness, and insomnia. Seek medical care or call 911 at once if you have the following serious. Common Cymbalta side effects may include: drowsiness; nausea, constipation, loss of appetite; dry mouth; or increased sweating. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Cymbalta can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while taking Cymbalta. These lists do not include all possible. Cymbalta, which is used to treat depression, can cause side effects. Learn about its more common, mild, and serious side effects and how to manage them. Cymbalta is a depression and anxiety medication. Here are 13 side effects to know before taking Cymbalta and when to consult your prescriber.