Learn about Depakote (divalproex sodium), which is a drug used to treat certain kinds of seizures and bipolar episodes and prevent migraine headaches. Available in two strengths, Depakote ER contains the same active ingredient as Depakote Tablets but it is designed to slowly deliver the medication over a 24-hour period. What Is Valproate And What Does It Treat? Valproate is a mood stabilizer medication that works in the brain. It is approved for treatment of mania associated with bipolar disorder (also known as manic depression), seizures (epilepsy), and migraine headaches. Bipolar disorder involves episodes of depression and/or mania. What is Depakote ER? Depakote ER comes in different pill forms that are for different uses. Depakote ER tablets and capsules are used to treat seizures in people with epilepsy who are at least 10 years old. This medicine tablets are sometimes used together with other seizure medications. Depakote (Depakote Divalproex Sodium Tablets) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. DEPAKOTE® (divalproex sodium) delayed-release tablets and DEPAKOTE® ER (divalproex sodium) extended-release tablets are prescription medicines used: DEPAKOTE ER and DEPAKOTE are also used to prevent migraine headaches. Divalproex sodium is used to treat certain types of seizures (epilepsy). This medicine is an anticonvulsant that works in the brain tissue to stop seizures. Divalproex sodium is also used to treat the manic phase of bipolar disorder (manic-depressive illness) and helps prevent migraine headaches. Find patient medical information for Divalproex Sodium (Depakote, Depakote ER, Depakote Sprinkles) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and. Drug Safety Update - Valproate medicines (Epilim, Depakote): contraindicated in women and girls of childbearing potential unless conditions of Pregnancy Prevention Programme are met. Depakote tablets and capsules are used to treat seizures in people with epilepsy who are at least 10 years old. The tablets are sometimes used together with other seizure medications.