Depakote ER is a valproate and is indicated for the treatment of acute manic or mixed episodes associated with bipolar disorder, with or without psychotic features. Find patient medical information for Divalproex Sodium (Depakote, Depakote ER, Depakote Sprinkles) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and. Depakote tablets and capsules are used to treat seizures in people with epilepsy who are at least 10 years old. The tablets are sometimes used together with other seizure medications. DEPAKOTE® (divalproex sodium) delayed-release tablets and DEPAKOTE® ER (divalproex sodium) extended-release tablets are prescription medicines used: DEPAKOTE ER and DEPAKOTE are also used to prevent migraine headaches. Divalproex sodium is used to treat certain types of seizures (epilepsy). This medicine is an anticonvulsant that works in the brain tissue to stop seizures. Divalproex sodium is also used to treat the manic phase of bipolar disorder (manic-depressive illness) and helps prevent migraine headaches. What is Depakote ER? Depakote ER comes in different pill forms that are for different uses. Depakote ER tablets and capsules are used to treat seizures in people with epilepsy who are at least 10 years old. This medicine tablets are sometimes used together with other seizure medications. Depakote (Depakote Divalproex Sodium Tablets) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Depakote Sprinkle® capsules: Swallow whole or sprinkle onto food, such as applesauce or pudding and eat immediately. Do not chew the sprinkle capsule or contents. Drug Safety Update - Valproate medicines (Epilim, Depakote): contraindicated in women and girls of childbearing potential unless conditions of Pregnancy Prevention Programme are met. Depakote Sprinkle Capsules are indicated as monotherapy and adjunctive therapy in the treatment of adult patients and pediatric patients down to the age of 10 years with complex partial seizures.