DMPA is reversible and can be used by patients of all ages, including adolescents. DMPA does not protect against STIs, including HIV infection, and patients using DMPA should be counseled that consistent and correct use of external (male) latex condoms reduces the risk for STIs, including HIV infection. [31]. Depo-Provera is a birth control method that you can get as a shot. Learn more about the benefits, how well it works, and its side effects. Depo-Provera is used to prevent pregnancy and manage medical conditions linked to the menstrual cycle. A healthcare professional might suggest Depo-Provera if: You don't want to take a birth control pill every day. You can't or don't want to use estrogen. Women who use Depo-Provera Contraceptive Injection (Depo-Provera CI) may lose significant bone mineral density. Bone loss is greater with increasing duration of use and may not be. Commonly referred to as the “birth control shot,” Depo-Provera® is an injectable form of birth control. It’s a shot of progestin that you get every three months, most commonly in your arm or butt. You don’t have to take a daily pill, and it’s very effective when you take it as scheduled. Depo-Provera is a drug, manufactured by The Upjohn Co., whose active ingredient is medroxyprogesterone acetate (MPA). FDA first approved the drug in 1959 to treat amenorrhea,5 irregular uterine bleeding, and threatened and habitual abortion. This product information is intended only for residents of the United States. NHS medicines information on medroxyprogesterone contraceptive injections – what they're used for, side effects, dosage and who can have them. Depo-Provera is a shot that prevents pregnancy for up to 3 months. Learn how this birth control method works, how and when to use it, and how effective it is. Depo-Provera CI is an intramuscular injection (shot injected into a muscle) and is used as a contraceptive to prevent pregnancy. Depo-Provera does not protect against HIV infection (AIDS) and other sexually transmitted diseases (STDs).