Lexapro can cause changes in weight. There are some reports that people begin to lose weight when first taking Lexapro, but this finding is not well supported by research studies. Up to one-third of people taking Lexapro (escitalopram) put on 5–15 lb within the first year. The weight gain is usually dose-related and driven by increased appetite and slowed metabolism. While Lexapro can cause weight gain in some people, it typically causes less weight increase than medications like paroxetine (Paxil) or mirtazapine (Remeron), which are associated with more frequent and significant weight gain. Clinical research has documented that people taking SSRI antidepressants like Lexapro experience weight gain of less than 7% overall of their starting body weight, although this varies from study to study, and from person to person. The antidepressant medication Lexapro has been linked to weight gain. A recent study links antidepressants to weight changes. Lexapro (escitalopram) can cause weight gain, but the amount is relatively modest for most people: about 1.4 pounds at six months and 3.6 pounds at two years, based on a large analysis of electronic health records published by Harvard Health. Lexapro (escitalopram) is a medication doctors prescribe to treat anxiety and depression. It increases serotonin in the brain, which can affect appetite and may lead to weight changes. Does Lexapro cause weight gain? Lexapro (escitalopram) can cause modest weight gain in some people, especially with longer-term use, but it doesn't affect everyone the same way. Yes, Lexapro (escitalopram) can cause weight gain in some adults, but the relationship is more nuanced than a simple yes or no. Research shows that most people taking Lexapro experience modest weight changes — typically 1 to 5 pounds — rather than the dramatic gains many people fear. Lexapro can cause weight gain, especially with long-term use. Learn why this happens and how to manage this side effect.