This seven-night AmaWaterways cruise journeys along Colombia's Magdalena River, sailing from colorful Cartagena to the verdant, untouched landscapes of the Colombian riverbanks. We rank the 7 Best Cheap Vacations in Central and South America. See which places our readers like the best, and vote for your favorites. Cartagena spreads across Colombia's Caribbean coast. Except for their airplanes landing in the north, a majority of travelers' time is spent in the eastern area of the city. This coastal portion. From Miami, Oceania Vista calls at George Town, Cayman Islands; Cartagena, Colombia; Puerto Quetzal, Guatemala; Acapulco and Manzanillo, Mexico; and San Diego before ending in Los Angeles. Guide to the best hotels and things to do in Cartagena. Maps, travel tips and more. Sanctuary of Saint Peter Claver is ranked 5 out of 12 things to do in Cartagena. See pictures and our review of Sanctuary of Saint Peter Claver. The best way to get around Cartagena is by taxi. Taxis make it easy to get between distinct points in the city, including Cartagena's Rafael Núñez International Airport (CTG), while short jaunts. Ranking of the top 12 things to do in Cartagena. Travelers favorites include 1 Old City Walls, 2 San Felipe de Barajas Castle and more. Guide to the best hotels and things to do in Cartagena. Maps, travel tips and more. Best Hotels in Cartagena for 2026 Hotels ranked on industry awards, guest reviews and hotel class ratings How We Rank Hotels Unbiased content created by U.S. News editors.