Doxycycline can interact with certain medications, supplements, and foods. Examples include blood thinners, such as warfarin, antacids, birth control pills, certain seizure medications, and. It’s a popular medication for treating bacterial infections, but it has a few interactions to be aware of. Many prescription medications can interact with doxycycline. Certain over-the-counter medications and supplements can, too; including antacids, iron supplements, and Pepto-Bismol. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Find out about possible interactions between doxycycline and other medications, supplements, alcohol, foods, and more. Find patient medical information for Doxycycline on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Does doxycycline interact with my other drugs? Enter medications to view a detailed interaction report using our Drug Interaction Checker. Other drugs may interact with doxycycline, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. 246 medications are known to interact with doxycycline. Includes: drug, food, pregnancy, breastfeeding and therapeutic duplication warnings. See the list of drugs that interact with Doxycycline. Includes information on severity of interaction and the level of evidence for it. Doxycycline interacts with several common medications, supplements, and foods, which can reduce its effectiveness or cause side effects. Avoid taking doxycycline with antacids, calcium supplements, iron, or magnesium, as these minerals block absorption into the bloodstream.