Doxycycline may interact with antacids and penicillin antibiotics like amoxicillin. See more common doxycycline interactions and tips for avoiding them here. Doxycycline capsules, delayed-release capsules, delayed-release tablets, and tablets and Acticlate® Cap capsules are also used to prevent malaria and treat anthrax infection after possible exposure and other conditions as determined by your doctor. Doxycycline belongs to the class of medicines known as tetracycline antibiotics. Understanding Doxycycline Interactions for Safe Usage Doxycycline is a commonly prescribed antibiotic used to treat many bacterial infections, including acne, respiratory infections, Lyme disease, and some sexually transmitted infections. It works by stopping bacteria from making the proteins they need to grow, helping. Doxycycline Interactions There are 237 drugs known to interact with doxycycline, along with 3 disease interactions, and 2 alcohol/food interactions. Of the total drug interactions, 22 are major, 210 are moderate, and 5 are minor. See the list of drugs that interact with Doxycycline. Includes information on severity of interaction and the level of evidence for it. Medscape's Drug Interaction Checker helps you build safer, more effective treatment plans by quickly identifying potential interactions between medications, supplements, and even common foods. Find out about possible interactions between doxycycline and other medications, supplements, alcohol, foods, and more. 237 medications are known to interact with doxycycline. Includes: drug, food, pregnancy, breastfeeding and therapeutic duplication warnings. Use WebMD’s Drug Interaction Checker to identify potential interactions between medications, supplements, and foods. Reduce side effects and support safer treatment decisions. Find out about possible interactions doxycycline has with alcohol, other drugs, supplements, and foods.