Use WebMD’s Drug Interaction Checker to identify potential interactions between medications, supplements, and foods. Reduce side effects and support safer treatment decisions. Use our drug interaction checker to find potentially harmful drug, food, and alcohol interactions. Type a drug name in the box above to get started. Not all drugs interact, and not every interaction means you must stop taking one of your medications. Medscape's Drug Interaction Checker helps you build safer, more effective treatment plans by quickly identifying potential interactions between medications, supplements, and even common foods. Display complete list of interactions for an individual item by clicking item name. Add another item to analyze for potential interactions. NOTE: This tool does not address chemical compatibility related to I.V. drug preparation or administration. A drug interaction occurs when one medication changes the way another medication works in your body. Interactions can increase a drug's side effects, reduce its effectiveness, or — in serious cases — cause life-threatening reactions. Check for drug interactions and learn what drug combinations to avoid with the RxList drug interaction checker tool.