In response to this, an updated literature search on prophylaxis for medical patients who were hospitalized and those who were not hospitalized was carried out. The purpose of this article is to report the main findings from this updated literature search. Hospitalization for acute medical illness is an important opportunity for applying prevention efforts. These guidelines address methods to prevent VTE in hospitalized and non-hospitalized medical patients and long-distance travelers. Access the full guidelines on the Blood Advances website: Deep Venous Thrombosis Prophylaxis refers to the preventive measures taken to avoid the formation of blood clots in the deep veins, typically in the legs, which can lead to serious health complications. The Padua Prediction Score is a risk assessment model (RAM) for the identification of patients at risk of VTE. Reassess the score throughout hospitalization, as new risk factors (e.g., central venous catheter placement, infection requiring IV antibiotics, prolonged immobility) can add points and change prophylaxis decisions. Despite appropriate DVT prophylaxis, surgical patients may still develop both DVT and PE. A 2014 case-control study identified five independent predictors of in-hospital DVT despite chemoprophylaxis. DVT prophylaxis involves a range of preventive measures that aim to reduce the risk of DVT and subsequent complications. Treatment to prevent deep venous thrombosis is required for patients who are bedbound with major illness and/or those undergoing certain surgical procedures. Early mobilization, leg elevation, and an anticoagulant are the recommended preventive measures; patients who should not receive anticoagulants may benefit from intermittent pneumatic compression devices or elastic stockings. Venous thromboembolism (VTE) prophylaxis consists of pharmacologic and nonpharmacologic measures to diminish the risk of deep vein thrombosis (DVT) and pulmonary embolism (PE). In acutely ill hospitalized medical patients, the panel recommends inpatient over inpatient plus extended duration outpatient VTE prophylaxis (strong recommendation, moderate certainty).