Erythromycin is excreted in the urine and bile, but only a fraction of the total dose can be accounted for by these two excretory routes. Although erythromycin is uniformly distributed throughout most of the body, concentrations in CSF are low, even in the presence of meningeal inflammation. Detailed Erythromycin dosage information for adults and children. Includes dosages for Bacterial Infection, Bronchitis, Skin or Soft Tissue Infection and more; plus renal, liver and dialysis adjustments. Erythromycin estolate, a macrolide antibiotic, was introduced in 1958 for the treatment of gram-positive infections. By the early 1970s its use had been associated with a higher incidence of hepatic toxicity than that seen with other salts and esters of erythromycin. Erythromycin may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop using this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. Erythromycin is easily inactivated by gastric acid; therefore, all orally administered formulations are given as either enteric-coated or more-stable salts or esters, such as erythromycin ethylsuccinate. Erythromycin is a macrolide antibiotic used to treat bacterial infections. Includes erythromycin side effects, interactions and indications. Erythromycin estolate diffuses through the bacterial cell membrane and reversibly binds to the 50S subunit of the bacterial ribosome. This prevents bacterial protein synthesis. Express the result as erythromycin A estolate, erythromycin B estolate and erythromycin C estolate by multiplying the percentage content of erythromycin A by 1.4387, the percentage content of erythromycin B by 1.4485 and the percentage content of erythromycin C by 1.4472. The estolate form of erythromycin is an esterified derivative designed to enhance the drug’s stability and bioavailability. When erythromycin estolate is ingested, it is absorbed in the digestive tract and converted by enzymatic action into its active form, erythromycin. Erythromycin estolate is defined as an ester formulation of erythromycin that is absorbed intact from the intestine, where plasma esterases subsequently release the active drug. How useful is this definition? You might find these chapters and articles relevant to this topic.