Learn about estradiol (Estrace) vaginal cream usage and dosing. Read the latest news and reviews about the drug as well as potential side effects and popular alternatives. Estrogens combined with smoking further increases your risk of stroke, blood clots, high blood pressure, and heart attack, especially in women older than 35. Estrace (Estradiol) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Find patient medical information for Estradiol (Delestrogen, Depo-Estradiol, Estrace) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Estrace is used to treat menopause symptoms such as hot flashes and vaginal changes, and to prevent osteoporosis (bone loss) in menopausal women, and to replace estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Estradiol tablet is an estrogen hormone used to treat menopause symptoms like hot flashes, night sweats, and vaginal irritation. It also helps prevent bone loss (osteoporosis) after menopause. Though not as common, it's also FDA approved to treat certain advanced stages of breast and prostate cancer. Premarin® versus Estrace®: Learn how these two estrogens compare on safety, delivery, and cost, plus what a new generic means for access. COMMON BRAND NAME (S): Estrace. What should I tell my care team before I take this medication? They need to know if you have any of these conditions: How should I use this medication? This medication is for use in the vagina only. Do not take by mouth. Follow the directions on the prescription label. Read package directions carefully before using. Estrace Vaginal (for use in the vagina) is used in menopausal adult women to treat certain symptoms of menopause such as dryness, itching, irritation, and pain during sexual intercourse. Estrace is FDA-approved for treating moderate to severe menopause symptoms, including hot flashes and vaginal atrophy. The vaginal cream specifically targets genitourinary symptoms like vaginal dryness, irritation, and discomfort during intercourse.