Learn about the side effects of estradiol, from common to rare, for consumers and healthcare professionals. Estradiol is a female hormone (estrogen). It is used by women to help reduce vaginal symptoms of menopause. Learn about side effects, drug interactions, dosages, warnings, and more. Estradiol (E2), also called oestrogen, oestradiol, is an estrogen steroid hormone and the major female sex hormone. It is involved in the regulation of female reproductive cycles such as estrous and menstrual cycles. Estradiol is an estrogen hormone. The hormone from the patch, gel, and spray is absorbed through your skin into your body. This medicine is available only with your doctor's prescription. Estradiol is a form of estrogen, a female sex hormone that regulates many processes in the body. It is available as an oral tablet, a topical gel or patch, vaginal cream, or as an injection. Estradiol (E2) is the most potent and clinically measured form of estrogen. It is produced primarily in the ovaries in women, in small amounts by the testes in men, and in fat tissue in both sexes. Find patient medical information for Estradiol (Delestrogen, Depo-Estradiol, Estrace) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Estradiol (Estrace, Vivelle-Dot, Climara) is a moderately priced drug used to treat hot flashes and osteoporosis. It is also used to treat women with low estrogen levels or those who have had their ovaries removed. Estradiol is a drug prescribed to treat the symptoms of menopause and prevent bone fractures (osteoporosis), painful uterine bleeding, vaginal pain, dryness, and atrophy associated with menopause. Estradiol is also prescribed for the treatment of breast cancer, and some cases of prostate cancer. Estradiol is used in menopausal hormone therapy to prevent and treat moderate to severe menopausal symptoms such as hot flashes, vaginal dryness and atrophy, and osteoporosis (bone loss). [11].