The estrogen patch is a form of hormone replacement therapy (HRT) that delivers a steady dose of estradiol (e2) through your skin to your bloodstream. Estradiol patches can ease menopause symptoms like hot flashes, night sweats, and sleep trouble, and help prevent bone loss. Estradiol transdermal gel, patch, and spray are used to treat moderate to severe symptoms of menopause (eg, feelings of warmth in the face, neck, and chest, or sudden strong feelings of heat and sweating [hot flashes]) in women with a uterus. An estrogen patch, or estradiol transdermal patch, is a form of hormone replacement therapy that can help treat menopause symptoms like hot flashes and night sweats. Estradiol transdermal skin patches are used to treat certain symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. estradiol transdermal is also used to prevent postmenopausal osteoporosis, or to treat ovarian disorders. An estradiol patch reduces the number and severity of hot flashes caused by menopause. If you have a hot flash, you’ll experience a sudden flare of heat, sweating and flushed skin. What is an estradiol patch? An estradiol patch is a type of hormone replacement therapy (HRT) used to treat symptoms of menopause, like hot flashes and vaginal dryness or itching. The patch releases a continuous dose of estrogen that is absorbed transdermally, or through the skin. Many women have found that estrogen patches are a convenient solution for hormone replacement therapy. Learn how estrogen patches are used, side effects, and cost. Estradiol (Estrace, Vivelle-Dot, Climara) is a moderately priced drug used to treat hot flashes and osteoporosis. It is also used to treat women with low estrogen levels or those who have had their ovaries removed. Over the last year, the supply of FDA-approved estradiol transdermal patches has nearly doubled. Manufacturers continue to take steps to make more patches available. What is Estradiol Patch? Estradiol is a form of estrogen, a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body. Estradiol Patches are used to treat certain symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation.