Learn about side effects, cost, uses, and more of Femara (letrozole), which is a prescription drug that treats breast cancer in certain females. Femara® (letrozole tablets) is indicated for the adjuvant treatment of postmenopausal women with hormone receptor positive early breast cancer (see CLINICAL STUDIES). Femara is a treatment that may be used to reduce the risk of breast cancer recurrence in postmenopausal women and also to increase the chance of ovulation in women with polycystic ovary syndrome. Letrozole, sold under the brand name Femara among others, is an aromatase inhibitor medication that is used in the treatment of breast cancer for post-menopausal women. Find patient medical information for Letrozole (Femara) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Drug Summary What Is Femara? Femara (letrozole) is a non-steroidal aromatase inhibitor (lowers estrogen production) used to treat breast cancer in postmenopausal women. Femara is often given to women who have been taking tamoxifen (Nolvadex, Soltamox) for 5 years. Femara is available in generic form. What Are Side Effects of Femara? “I’m on my third year of Femara and am tolerating it well. I categorize my side effects as ‘inconsistent and somewhat annoying.’ For example; I have sporadic instances of calf and arch cramps; intense sweating, joint pain and stiffness — but never all at once and not day after day. 1.2 Extended Adjuvant Treatment of Early Breast Cancer Femara is indicated for the extended adjuvant treatment of early breast cancer in postmenopausal women, who have received 5 years of. Femara lowers estrogen levels and is used to treat breast cancer in postmenopausal women. Learn about side effects, interactions and indications. Description Letrozole is used to treat certain types of breast cancer in women who have already stopped menstruating (postmenopausal). It is also used for women who have already had other cancer treatments (eg, tamoxifen). Female hormones that occur naturally in the body can increase the growth of some breast cancers. Letrozole works by decreasing the amounts of these hormones in the body.