Metronidazole is a nitroimidazole antimicrobial that kills anaerobic bacteria and parasites via DNA-damaging free radicals. It treats trichomoniasis, amebiasis, and serious anaerobic infections, and prevents post-colorectal-surgery infection. Learn about side effects, interactions, and indications. Can metronidazole monotherapy still be used to treat CDI? Metronidazole monotherapy is inferior to oral vancomycin (and, by extension, fidaxomicin) for clinical cure in most patients. Administration of FLAGYL 375 capsules with food does not affect the extent of absorption of metronidazole; however, the presence of food results in a lower C max and a delayed T max compared to fasted conditions. Medscape - Amebiasis-specific dosing for Flagyl, Flagyl ER (metronidazole), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and. Flagyl, Flagyl ER, and Flagyl Injection (metronidazole) are antimicrobial drugs used to treat bacterial vaginosis, trichomonas, amebiasis, and anaerobic bacterial infections. Following oral administration, the peak plasma concentration is reached between 1–2 hours. Plasma concentrations of oral metronidazole are proportional to the administered dose. Flagyl is used to treat bacterial infections of the vagina, stomach, skin and joints. Learn about side effects, interactions and indications. Metronidazole is one of the mainstay drugs for the treatment of anaerobic infections [1,2]. It is approved by the US Food and Drug Administration (FDA) for the treatment of anaerobic and protozoal infections. Dosage Forms: IV PO: 250mg; 375mg; 500mg Common Trade Names: Flagyl Adult Dosing General PO 500mg PO q6-8h x 7-10 days First Dose: 500mg PO x 1 IV 15mg/kg IV x1, then 7.5mg/kg IV q6h First Dose: 15mg/kg IV x1 Max: 1 gram/dose Indications by Disease. Pediatric Dosing ( 1200g) 7.5 mg/kg PO/IV q48h First Dose: 7.5 mg/kg PO/IV x 1 ( 1200g AND 1. Metronidazole belongs to the class of medicines known as antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections. This medicine is available only with your doctor's prescription.