Diphenhydramine, also known by the brand name Benadryl, is an over-the-counter antihistamine used to relieve allergy or common cold symptoms in adults and children. Benadryl USA shoppers choose fast, familiar allergy relief for sneezing, itching, and watery eyes. Benadryl is an antihistamine that helps block histamine responses from everyday allergens. Benadryl is an antihistamine and is used to treat sneezing, runny nose, itching and other allergies. Learn about side effects, interactions and indications. Discover antihistamine solutions with diphenhydramine to help manage seasonal allergens. Many allergy tablets labeled as comparable products list diphenhydramine HCl as the active ingredient. That name is what you’ll typically see on the Drug Facts panel for the generic version. Match the strength and dosage form (tablet, capsule, or liquid gel) to what you prefer. Diphenhydramine hydrochloride is a medication that is approved by the U.S. Food and Drug Administration for treating symptoms of allergies. The drug is available for purchase over the counter without a doctor's prescription. Shop diphenhydramine antihistamine tablets to manage allergy symptoms. Find 25mg options for relief from sneezing, runny nose, and itchy eyes. Find patient medical information for Diphenhydramine (Benadryl, Unisom, and others) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Benadryl (diphenhydramine) is an allergy medicine that often makes people sleepy, so it may feel calming for a few hours. But drowsiness is not the same as treating anxiety, and Benadryl is not FDA-approved for anxiety. The generic version of Benadryl is called diphenhydramine. A generic drug is an exact copy of the active drug in a brand-name medication and considered as safe and effective as the original drug.