Percocet (oxycodone and acetaminophen) is a combination drug consisting of an opioid and a pain reliever and fever reducer (analgesic and antipyretic) used for the management of moderate to severe pain, usually for an extended time period. Oxycodone/acetaminophen is a combination medicine used to treat severe pain. Oxycodone is an opioid that binds to pain receptors; acetaminophen helps block pain signals. Learn about Percocet (oxycodone / acetaminophen) usage and dosing. Read the latest news and reviews about the drug as well as potential side effects and popular alternatives. Percocet is a prescription painkiller combining oxycodone and acetaminophen. It's used for severe pain when other non-opioid pain treatments haven't worked or cannot be tolerated. Includes Percocet side effects, interactions, and indications. Oxycodone hydrochloride is the generic name for the opiate pain reliever in Percocet. This narcotic drug is chemically similar to morphine and has been in use as a pain reliever since 1917. Wondering when a generic version of OxyContin will be available? Get details on FDA approval status, generic manufacturers, and patent expirations. Learn what Percocet is, how it works for pain relief, common side effects, and risks. Plus, treatment options if you're concerned about dependency. Oxycodone is a full opioid agonist with relative selectivity for the mu-opioid receptor, although it can interact with other opioid receptors at higher doses. The principal therapeutic action of oxycodone is analgesia. Oxycodone / acetaminophen (Endocet, Percocet, prolate, nalocet) is a moderately priced drug used to treat moderate to severe pain.This drug is more popular than comparable drugs. It is available in multiple brand and generic versions. Many opioids go by different names. Some appear on labels as brand names, while others are listed by their generic names. Both can be strong, addictive, and carry serious risks. This guide outlines common generic and brand-name pairs and helps you identify these drugs on a prescription label.