Find patient medical information for Hydrocodone/Acetaminophen (Norco, Vicodin, others) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Easy-to-read patient tips for acetaminophen/hydrocodone covering how it works, benefits, risks, and best practices. Hydrocodone and acetaminophen is a Schedule II controlled substance. All branded hydrocodone and acetaminophen (Norco, Vicodin, Lortab, Hycet, Lorcet, Verdrocet, Xodol, Zamicet) have been discontinued, but generic hydrocodone and acetaminophen tablets and oral solution is still available. Hydrocodone/Acetaminophen is a prescription medication used to treat Moderate to Severe Pain. Learn about side effects, dosages, drug interactions, and more. Hydrocodone and acetaminophen combination is used to relieve pain severe enough to require opioid treatment and when other pain medicines did not work well enough or cannot be tolerated. Hydrocodone/acetaminophen is a narcotic drug used as a pain reliever to treat moderate to moderately severe pain and cough suppressant. Side effects include lightheadedness, dizziness, sedation, nausea, and vomiting. Hydrocodone Acetaminophen 5-325 is a widely prescribed painkiller, combining an opioid and a non-opioid analgesic. While effective for managing moderate to severe pain, its potential for misuse, dependence, and addiction raises significant concerns.