What is this medication? HYDROCODONE; CHLORPHENIRAMINE (hye droe KOE done; klor fen IR a meen) treats the symptoms of the common cold, allergies, or flu. It works by reducing cough, a runny or stuffy nose, and red, itchy eyes. It is a combination of an opioid cough suppressant and an antihistamine. Hydrocodone/chlorpheniramine is a combination medication containing an opioid and an antihistamine. It's a prescription cough syrup for adults to temporarily relieve cough and other respiratory symptoms related to allergies or the common cold, like runny nose and sneezing. Hydrocodone is a narcotic cough suppressant. It affects the signals in the brain that trigger cough reflex. Chlorpheniramine and hydrocodone is a combination medicine used to treat runny nose, sneezing, itching, watery eyes, and cough caused by allergies, the common cold, or the flu. Hydrocodone and chlorpheniramine combination is used to relieve cough and nasal congestion (stuffy nose) associated with the common cold or allergy in adults. Hydrocodone is an opioid antitussive (cough suppressant). It acts directly on the cough center in the brain to relieve cough. Hydrocodone is a semisynthetic narcotic antitussive and analgesic with multiple actions qualitatively similar to those of codeine. The precise mechanism of action of hydrocodone and other opiates is not known; however, hydrocodone is believed to act directly on the cough center. HYDROCODONE; CHLORPHENIRAMINE treats the symptoms of the common cold, allergies, or flu. It works by reducing cough, a runny or stuffy nose, and red, itchy eyes. It is a combination of an opioid cough suppressant and an antihistamine. Read the Medication Guide and, if available, the Patient Information Leaflet provided by your pharmacist before you start taking hydrocodone/chlorpheniramine and each time you get a refill. Hydrocodone and chlorpheniramine polistirex combination is used to treat cough and respiratory symptoms associated with a cold or allergy. Hydrocodone polistirex is an opioid cough suppressant. It acts directly on the cough center in the brain to prevent a cough. Overview: Hydrocodone/chlorpheniramine is a combination medicine taken for coughing and other symptoms like a runny nose, sneezing, and a stuffy nose from allergies or the common cold. Common. Tussionex (chlorpheniramine and hydrocodone) is a combination antihistamine/antitussive drug prescribed for symptomatically managing cold and allergy symptoms. What Are Side Effects of Tussionex? Common side effects of Tussionex include: disturbed coordination. Contact your doctor if you have serious side effects of Tussionex including.