Hydroxyzine is used to treat itching caused by allergies. It is an antihistamine and works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Hydroxyzine pamoate and hydroxyzine HCl both deliver the same active drug, hydroxyzine, so their clinical effects (such as sedation, itch relief, and anxiety reduction) are broadly similar. Hydroxyzine hydrochloride and hydroxyzine pamoate (Vistaril) are two versions of the same treatment. Hydroxyzine pamoate is available as a brand and generic medication. Hydroxyzine Pamoate package insert / prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions and pharmacology. well-controlled studies in humans. Hydroxyzine may be used in the second and third trimesters of pregnancy, but it should not be used during or just prior to labor. Use of hydroxyzine during labor may increase seizure risk in infants, decrease fetal heart rate, and increase side e Hydroxyzine is used to help control anxiety and tension caused by nervous and emotional conditions. It can also be used to help control anxiety and produce sleep before surgery. Find patient medical information for Hydroxyzine (Atarax, Vistaril, and others) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Know what Hydroxyzine Pamoate is used for, how to take it, and which side effects to expect when starting it. Learn about hydroxyzine pamoate (Vistaril) usage and dosing. Read the latest news and reviews about the drug as well as potential side effects and popular alternatives. Hydroxyzine pamoate is the active ingredient found in a medication commonly referred to by its brand name, Vistaril. The medication, which initially was released as an antihistamine, is now also being used as a mild sedative to treat problems including insomnia, anxiety, itching, rashes, nervousness, mood disorders and dementia.