Wondering if ibuprofen can reduce heavy periods? A Northwestern Medicine gynecologist has answers. Long-term ibuprofen use can increase your risk of bleeding and ulcers in your stomach and intestines. If you take ibuprofen regularly, you can take steps to prevent peptic ulcers and protect. Understanding Ibuprofen Side Effects Ibuprofen is one of the most popular over-the-counter medications used to reduce pain, inflammation, and fever. Many people rely on it for headaches, muscle aches, or minor injuries. While it’s effective, like any medicine, Ibuprofen can cause side effects. Some are mild and go away quickly, but others can be more serious and require medical attention. Ibuprofen is a widely used over-the-counter medication belonging to the class of nonsteroidal anti-inflammatory drugs (NSAIDs), commonly taken to relieve pain, reduce fever, and decrease inflammation. While effective, Ibuprofen carries a risk of causing gastrointestinal side effects, ranging from mild indigestion to serious conditions like stomach ulcers and internal bleeding. The mechanism. Description Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain, and helps to relieve symptoms of arthritis (osteoarthritis, rheumatoid arthritis, or juvenile arthritis), such as inflammation, swelling, stiffness, and joint pain. Ibuprofen is a widely used nonsteroidal anti-inflammatory drug (NSAID) taken to manage pain, fever, and inflammation. Ibuprofen does not stop bleeding; rather, it can prolong the time it takes for blood to clot. Also tell your doctor if you have or have ever had ulcers, bleeding in your stomach or intestines, or other bleeding disorders. If you experience any of the following symptoms, stop taking ibuprofen and call your doctor: stomach pain, heartburn, vomit that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools. Ibuprofen can cause internal bleeding, particularly in the stomach or intestines, especially with long-term or high-dose use. Learn about the side effects of ibuprofen, from common to rare, for consumers and healthcare professionals. Overview of nonsteroidal anti-inflammatory drugs (NSAIDs), their uses, benefits, and considerations for effective medical care.