Oats contain several components that have been proposed to exert health benefits. The primary type of soluble fiber in oats is beta-glucan, which has been researched to help slow digestion, increase satiety, and suppress appetite. Beyond convenience, oats stand out for their soluble fiber—especially beta-glucan—which helps maintain healthy cholesterol levels when eaten as part of a heart-smart pattern. They also supply magnesium, phosphorus, zinc, and B-vitamins that support metabolism and recovery. Learn how phytic acid in oats affects mineral absorption—and practical, evidence-informed ways to reduce it: soaking, fermenting, pairing, and choosing oat types. This short review summarizes the current knowledge about the beneficial effects of oat consumption, with emphasis on oat bioactive compounds responsible of the health-promoting attributes of this cereal and their underlying molecular mechanisms. Oats are a versatile and nutritious grain that contains phytic acid, a compound with potential concerns related to mineral absorption. However, the overall nutritional benefits of oats, including fiber, vitamins, and antioxidants, often outweigh these concerns in a balanced diet. The consumption of oats has been determined to be beneficial for human health by promoting immunomodulation and improving gut microbiota. In addition, oat consumption assists in preventing diseases such as atherosclerosis, dermatitis, and some forms of cancer. This is a detailed review of oats (a popular whole grain food), looking at its health benefits and nutritional properties. However, its high carbohydrate content can cause rapid spikes in blood sugar and insulin, especially when sweetened or processed. Oats may also contain gluten through cross-contamination and phytic acid, which can limit mineral absorption, making them less suitable for maintaining a balanced diet. Oats (Avena sativa L.) are a popular functional cereal grain due to their numerous health benefits. This review article summarized the information on the chemical composition and phytonutrients of oats grown in different countries. Thus, our systematic review aims to summarize and explore the evidence on the effect of oat intake on the GI health and the gut microbiome changes in individuals with GI conditions (CeD, IBD, and IBS) and without GI conditions.