Hydrochlorothiazide and lisinopril is a combination medicine used to treat hypertension (high blood pressure). Lowering blood pressure may lower your risk of a stroke or heart attack. Lisinopril and hydrochlorothiazide combination is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. The combination of lisinopril and hydrochlorothiazide is used to treat high blood pressure. Lisinopril is in a class of medications called angiotensin-converting enzyme (ACE) inhibitors. Lisinopril/hydrochlorothiazide (Zestoretic) is a combination of two medications: lisinopril and hydrochlorothiazide (HCTZ, for short). It’s prescribed to treat high blood pressure in adults. Detailed Hydrochlorothiazide / Lisinopril dosage information for adults. Includes dosages for Hypertension; plus renal, liver and dialysis adjustments. Lisinopril/hydrochlorothiazide, sold under the brand name Zestoretic among others, is a fixed-dose combination medication used for the treatment of high blood pressure (hypertension). [2] LISINOPRIL; HYDROCHLOROTHIAZIDE (lyse IN oh pril; hye droe klor oh THYE a zide) treats high blood pressure. It relaxes your blood vessels and helps your kidneys remove more fluid through the urine, which lowers blood pressure. This medication is a combination of an ACE inhibitor and diuretic. Find patient medical information for Lisinopril/Hydrochlorothiazide (Prinzide, Zestoretic) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Learn about Zestoretic (lisinopril / hydrochlorothiazide) usage and dosing. Read the latest news and reviews about the drug as well as potential side effects and popular alternatives. Lisinopril/Hydrochlorothiazide is a combination medicine used to treat hypertension. Learn about dosages, side effects, drug interactions, and warnings.