Lisinopril/Hydrochlorothiazide is a combination medicine used to treat hypertension. Learn about dosages, side effects, drug interactions, and warnings. Lisinopril/hydrochlorothiazide (Zestoretic) is an oral medication used to treat high blood pressure. Learn about side effects, warnings, dosage, and more. Know what Lisinopril-HCTZ is used for, how to take it, and which side effects to expect when starting it. What is lisinopril/hydrochlorothiazide used for? Lisinopril/hydrochlorothiazide is commonly used to lower high blood pressure (hypertension). Lowering high blood pressure has been shown to. Lisinopril/hydrochlorothiazide, sold under the brand name Zestoretic among others, is a fixed-dose combination medication used for the treatment of high blood pressure (hypertension). [2] Hydrochlorothiazide and lisinopril is a combination medicine used to treat hypertension (high blood pressure). Lowering blood pressure may lower your risk of a stroke or heart attack. Learn about Zestoretic (lisinopril / hydrochlorothiazide) usage and dosing. Read the latest news and reviews about the drug as well as potential side effects and popular alternatives. Lisinopril/hydrochlorothiazide (Zestoretic) is a combination of two medications: lisinopril and hydrochlorothiazide (HCTZ, for short). It’s prescribed to treat high blood pressure in adults. Description Lisinopril and hydrochlorothiazide combination is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. Learn about the side effects of hydrochlorothiazide/lisinopril, from common to rare, for consumers and healthcare professionals.