Define lo. lo synonyms, lo pronunciation, lo translation, English dictionary definition of lo. interj. Used to attract attention or to show surprise. American Heritage® Dictionary of the English Language, Fifth Edition. The word lo originates from the Old English lā, an exclamation used to draw attention. It later became a prominent term in Middle English, often appearing in religious or poetic texts to emphasize awe or wonder. The meaning of LO is —used to call attention or to express wonder or surprise. How to use lo in a sentence. Lo usually gives the adjective an abstract quality (as above). It can also refer to a thing, but el is more common in this case, e.g. el / lo blanco de los ojos (“the white of the eye”). LO definition: look! see! (frequently used in Biblical expressions; now usually used as an expression of surprise in the phraselo and behold ). See examples of lo used in a sentence. Translate Lo. See 8 authoritative translations of Lo in English with example sentences and audio pronunciations. This disambiguation page lists articles associated with the title Lo. If an internal link incorrectly led you here, you may wish to change the link to point directly to the intended article.