Metformin hydrochloride extended-release tablets should be started at a low dose, with gradual dose escalation, both to reduce gastrointestinal side effects and to permit identification of the minimum dose required for adequate glycemic control of the patient. The risk of metformin accumulation and metformin-associated lactic acidosis increases with the severity of renal impairment because metformin is substantially excreted by the kidney. Learn about metformin ER usage and dosing. Read the latest news and reviews about the drug as well as potential side effects and popular alternatives. Metformin tablets should be used together with dietary changes and exercise for better results. Metformin belongs to the drug class biguanides. Metformin works by reducing glucose absorption from the intestines, lowering liver glucose production, and improving insulin sensitivity. Overview: Metformin is medicine you take to help keep your blood sugar from getting too high. Common side effects may include stomach problems, such as diarrhea, nausea, vomiting, stomach pain. Metformin is available in two forms: immediate-release (IR) and extended-release (ER). Compared with metformin IR, the ER form is designed to release the medication at a slower rate. Metformin IR is usually taken multiple times a day, while metformin ER is taken once daily. Metformin Extended-Release Tablets What is this medication? METFORMIN (met FOR min) treats type 2 diabetes. It controls blood sugar (glucose) and helps your body use insulin effectively. Changes to diet and exercise are often combined with this medication. Metformin Extended Release Tablets package insert / prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions and pharmacology. Metformin is used together with proper diet and exercise to treat high blood sugar levels caused by type 2 diabetes. This medicine reduces the absorption of sugar from the intestines, reduces the release of stored sugar from the liver, and helps your body use sugar better. Metformin is the first-line medication for managing Type 2 Diabetes. It is highly effective for improving glycemic control with a low risk of hypoglycemia. Metformin is available in two primary oral formulations: Immediate Release (Metformin HCl) and Extended Release (Metformin ER or XR).