Metformin is available in two forms: immediate-release (IR) and extended-release (ER). Compared with metformin IR, the ER form is designed to release the medication at a slower rate. Metformin IR is usually taken multiple times a day, while metformin ER is taken once daily. Metformin Extended-Release Tablets What is this medication? METFORMIN (met FOR min) treats type 2 diabetes. It controls blood sugar (glucose) and helps your body use insulin effectively. Changes to diet and exercise are often combined with this medication. Metformin hydrochloride extended-release tablets should be started at a low dose, with gradual dose escalation, both to reduce gastrointestinal side effects and to permit identification of the minimum dose required for adequate glycemic control of the patient. Learn about metformin ER (Fortamet) usage and dosing. Read the latest news and reviews about the drug as well as potential side effects and popular alternatives. Metformin is used to treat high blood sugar levels that are caused by a type of diabetes mellitus or sugar diabetes called type 2 diabetes. With this type of diabetes, insulin produced by the pancreas is not able to get sugar into the cells of the body where it can work properly. Metformin may cause allergic reactions, which can be serious. Stop taking metformin and get help right away if you have any of the following symptoms of a serious allergic reaction. Metformin tablets should be used together with dietary changes and exercise for better results. Metformin belongs to the drug class biguanides. Metformin works by reducing glucose absorption from the intestines, lowering liver glucose production, and improving insulin sensitivity. Metformin Extended Release Tablets package insert / prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions and pharmacology. Metformin is the first-line medication for managing Type 2 Diabetes. It is highly effective for improving glycemic control with a low risk of hypoglycemia. Metformin is available in two primary oral formulations: Immediate Release (Metformin HCl) and Extended Release (Metformin ER or XR). Metformin oral tablet basics Metformin is classified as a biguanide. It is available as an immediate-release (IR) oral tablet and extended-release (ER) oral tablet.