Overview: Methotrexate is used to treat certain types of arthritis, cancer, and severe psoriasis. Common side effects include nausea or vomiting, upset stomach, and mouth sores. Serious side. Methotrexate treats certain leukemias and lymphomas, mycosis fungoides, rheumatoid arthritis, polyarticular juvenile idiopathic arthritis in children, and severe psoriasis in adults. Learn about side effects, interactions, and indications. Methotrexate, formerly known as amethopterin, is a chemotherapy agent and immune-system suppressant. It is used to treat cancer, autoimmune diseases, and ectopic pregnancies. Methotrexate is a type of drug called an antimetabolite. It treats rheumatoid arthritis by decreasing the activity of your immune system, treats psoriasis by slowing the growth of skin cells and treats cancer by slowing the growth of cancer cells. Methotrexate tablet is used alone or together with other medicines to treat several types of cancer, such as breast, head and neck, lung, blood (eg, acute lymphoblastic leukemia or ALL), bone, lymph node (eg, mycosis fungoides, relapsed or refractory non-Hodgkin lymphoma), or uterus cancer.