Methotrexate treats certain leukemias and lymphomas, mycosis fungoides, rheumatoid arthritis, polyarticular juvenile idiopathic arthritis in children, and severe psoriasis in adults. Learn about side effects, interactions, and indications. Learn about methotrexate usage and dosing. Read the latest news and reviews about the drug as well as potential side effects and popular alternatives. Methotrexate Sodium package insert / prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions and pharmacology. Find patient medical information for Methotrexate (Rheumatrex, Trexall, and others) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Each methotrexate tablet, USP contains 2.5 mg methotrexate equivalent to 2.74 mg methotrexate sodium and the following inactive ingredients: lactose (anhydrous), magnesium stearate, pregelatinized starch, sodium hydroxide pellets, sodium starch glycolate and purified water. Methotrexate is a medication that treats arthritis, psoriasis and other inflammatory conditions. Learn more about its uses and side effects. Description Methotrexate tablet is used alone or together with other medicines to treat several types of cancer, such as breast, head and neck, lung, blood (eg, acute lymphoblastic leukemia or ALL), bone, lymph node (eg, mycosis fungoides, relapsed or refractory non-Hodgkin lymphoma), or uterus cancer. Methotrexate, formerly known as amethopterin, is a chemotherapy agent and immune-system suppressant. It is used to treat cancer, autoimmune diseases, and ectopic pregnancies. It is used for cancers such as breast cancer, leukemia, lung cancer, lymphoma, gestational trophoblastic disease, and osteosarcoma, as well as autoimmune diseases such as psoriasis, rheumatoid arthritis, and Crohn's. Methotrexate is used to treat certain types of cancer and rheumatoid arthritis. Learn about side effects, drug interactions, dosages, warnings, and more. Methotrexate tablets can cause embryo-fetal toxicity, including fetal death. For non-neoplastic diseases, methotrexate tablets are contraindicated in pregnancy. For neoplastic diseases, advise patients of reproductive potential of the potential risk to a fetus and to use effective contraception (4, 5.1, 8.1, 8.3).