Find patient medical information for Metronidazole topical on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings What Is Metronidazole Topical and How Does It Work? Metronidazole Topical is a prescription medication used to treat inflammatory lesions of rosacea, a type of adult acne. What is metronidazole topical? Metronidazole topical (for the skin) is used to treat skin lesions caused by rosacea. Metronidazole topical may also be used for purposes not listed in this medication guide. Metronidazole is a nitroimidazole with antiprotozoal, antibacterial, and anti-inflammatory properties and is available in oral and topical formulations. The diverse mechanisms of action of metronidazole have expanded its utility across various dermatologic conditions. Metronidazole is a synthetic, nitroimidazole-derivative antibacterial and antiprotozoal agent and also has direct anti-inflammatory effects and effects on neutrophil motility, lymphocyte transformation, and some aspects of cell-mediated immunity. metroNIDAZOLE (Topical) reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI). Metronidazole is in a class of medications called nitroimidazole antimicrobials. It works by stopping the growth of bacteria. How should this medicine be used? Metronidazole comes as a cream, lotion, or gel to be applied to your skin. Apply once or twice a day. Use metronidazole exactly as directed. Learn about Topical metronidazole usage and dosing. Read the latest news and reviews about the drug as well as potential side effects and popular alternatives. Description Metronidazole topical gel is used to treat inflammatory lesions (pimples and red bumps) caused by rosacea. Rosacea is a skin disease that causes redness and pimples on your nose, cheeks, chin, and forehead. This medicine is available only with your doctor's prescription. Metronidazole gel USP (topical), 0.75%, is indicated for topical application in the treatment of inflammatory papules and pustules of rosacea.