Minivelle package insert / prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions and pharmacology. What is Minivelle used for? This medication is a hormone (estrogen). It is used by women to help reduce symptoms of menopause (such as hot flashes, vaginal dryness). These symptoms are caused by the body making less estrogen. MINIVELLE (estradiol transdermal system) contains estradiol in a multipolymeric adhesive. The system is designed to release estradiol continuously upon application to intact skin. Five dosage strengths of MINIVELLE are available to provide nominal in vivo delivery rates of 0.025, 0.0375, 0.05, 0.075, or 0.1 mg of estradiol per day via the skin. Minivelle is a brand-name estradiol transdermal patch used to treat moderate to severe menopause symptoms like hot flashes and night sweats. It's also prescribed to help prevent osteoporosis in postmenopausal women. Detailed dosage guidelines and administration information for Minivelle (estradiol). Includes dose adjustments, warnings and precautions. For US Audience Only. Minivelle is a transdermal patch that contains estradiol (an estrogen hormone) and is used to reduce hot flashes after menopause and postmenopausal osteoporosis. Estradiol Transdermal System is a prescription medicine patch that contains estradiol (an estrogen hormone). Estradiol Transdermal System is used to reduce moderate to severe hot flashes due to menopause and to help prevent postmenopausal osteoporosis (thin weak bones). Minivelle (estradiol patch) is a twice-weekly hormonal patch that treats moderate-to-severe vasomotor symptoms, like hot flashes and night sweats, caused by menopause. It can also prevent bone loss (osteoporosis) after menopause. It's a type of hormone replacement therapy. MINIVELLE (estradiol transdermal system) contains estradiol in a multipolymeric adhesive. The system is designed to release estradiol continuously upon application to intact skin.