Estradiol Transdermal System is a prescription medicine patch that contains estradiol (an estrogen hormone). Estradiol Transdermal System is used to reduce moderate to severe hot flashes due to menopause and to help prevent postmenopausal osteoporosis (thin weak bones). Compare prices and print coupons for Minivelle and other drugs at CVS, Walgreens, and other pharmacies. Prices start at $107.47. Minivelle is a brand-name estradiol transdermal patch used to treat moderate to severe menopause symptoms like hot flashes and night sweats. It's also prescribed to help prevent osteoporosis in postmenopausal women. MINIVELLE (estradiol transdermal system) contains estradiol in a multipolymeric adhesive. The system is designed to release estradiol continuously upon application to intact skin. MINIVELLE (estradiol transdermal system) contains estradiol in a multipolymeric adhesive. The system is designed to release estradiol continuously upon application to intact skin. Five dosage strengths of MINIVELLE are available to provide nominal in vivo delivery rates of 0.025, 0.0375, 0.05, 0.075, or 0.1 mg of estradiol per day via the skin. Minivellees are used to treat certain symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Minivelle is also used to prevent postmenopausal osteoporosis, or to treat ovarian disorders. Minivelle may also be used for purposes not listed in this medication guide. For US Audience Only. Minivelle package insert / prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions and pharmacology. Minivelle (estradiol patch) is a twice-weekly hormonal patch that treats moderate-to-severe vasomotor symptoms, like hot flashes and night sweats, caused by menopause. It can also prevent bone loss (osteoporosis) after menopause. It's a type of hormone replacement therapy. MINIVELLE (estradiol transdermal system) contains estradiol in a multipolymeric adhesive. The system is designed to release estradiol continuously upon application to intact skin.