It is available under a number of brand names including Advil, Brufen, Motrin, and Nurofen. [7][13] Ibuprofen was first sold in 1969 in the United Kingdom and in 1974 in the United States. [7][12] It is on the World Health Organization's List of Essential Medicines. [14] Motrin products are commonly used to treat fever and pain, including headaches, as well as inflammation. The main active ingredient in most products is ibuprofen. Motrin (ibuprofen) is a widely used over-the-counter pain reliever and anti-inflammatory medication. Dosage varies by age, weight, and medical condition, with specific guidelines for adults and children. For relief from muscle aches, fevers, cramps, & more, MOTRIN® is pain relief you can count on. Learn how MOTRIN® can help relieve pain for you & your child. Motrin Children's Dye-Free Chewable Tablets with Ibuprofen, Kids' Fever Reducer & Pain Reliever for Sore Throat, Fever, Toothache & Pain Relief, Grape Flavor, 24 Ct Motrin IB is a nonsteroidal anti-inflammatory drug (NSAID). Ibuprofen works by reducing hormones that cause inflammation and pain in the body. Motrin IB is used to reduce fever and treat pain or inflammation caused by many conditions such as headache, toothache, back pain, arthritis, menstrual cramps, or minor injury. In summary, Motrin, Motrin IB and Advil are all brands of ibuprofen so are equally effective. Because they are the same drug, Motrin, Motrin IB and Advil should NOT be taken together as this increases the risk of side effects such as stomach ulcers and bleeding. What Is MOTRIN®? Learn more about ibuprofen, the active ingredient in MOTRIN®, and how this NSAID can help reduce fever and relieve pain for all members of your family. Overview: Ibuprofen is used to reduce fever, pain, and swelling. It works by blocking certain substances in the body that cause pain, inflammation, and fever. Common side effects include stomach. Motrin (ibuprofen) is used to treat mild to moderate pain. Learn side effects, dosage, drug interactions, warnings, patient labeling, reviews, and more.