Nexium prevents acid reflux and gives the esophageal tissues time to heal. People will take their dose once daily, one hour before a meal. After four to eight weeks of treatment, the prescriber will transition to a smaller daily dose to maintain healing. NEXIUM 20 mg is indicated to maintain symptom resolution and healing of EE (controlled studies did not extend beyond 6 months). In infants 1 month to less than 1 year, NEXIUM is indicated for short-term treatment (up to 6 weeks) of EE due to acid-mediated gastroesophageal reflux disease (GERD). Your doctor may adjust your dose as needed. To prevent erosive esophagitis from coming back, your doctor may want you to take 20 mg once a day for up to 6 months. Detailed dosage guidelines and administration information for Nexium Capsules (esomeprazole magnesium). Includes dose adjustments, warnings and precautions. Adults Starting dosage is 40 mg twice daily4 (varies with the individual patient) as long as clinically indicated. A maximum dosage of 20 mg once daily is recommended for patients with severe. Adjust dose according to prescribing information if needed. The maximum over-the-counter Nexium dose is one capsule (20 mg) per day. With a prescription, the dose can go up to 40 mg once daily for more severe conditions like erosive esophagitis. In either case, Nexium is a once-daily medication, not something you increase when symptoms flare. NEXIUM prescription and dosage information for physicians and health care professionals. Pharmacology, adverse reactions, warnings, and NEXIUMside effects. Detailed dosage guidelines and administration information for Nexium (esomeprazole sodium). Includes dose adjustments, warnings and precautions. Esomeprazole, sold as Nexium, treats acid reflux. Here’s our guide to dosing Nexium for adults and children, and for times when dosage changes may be needed.