Omeprazole, approved by the FDA, is available as a prescription and over-the-counter (OTC) drug used as a treatment for frequent heartburn. Learn about side effects, drug interactions, dosages, warnings, and more. The recommended OTC omeprazole dosage to treat heartburn is 20 mg by mouth once daily in the morning for up to 14 days (2 weeks). You shouldn’t take OTC omeprazole for longer than 2 weeks. Omeprazole is a medication that treats conditions that cause too much stomach acid like heartburn, stomach ulcers and reflux disease. It works by reducing the amount of acid in your stomach. Patients under 20 kg should not take more than 20 mg of omeprazole per day. Common side effects of omeprazole include gas, nausea, constipation, vomiting, and headaches. In most cases, these are not severe and do not interrupt the patient's ability to use their medication. NHS information about the medicine omeprazole, including what it's used for, who can take it, how to take it and side effects. Easy-to-read patient tips for omeprazole covering how it works, benefits, risks, and best practices. Omeprazole is used to treat certain conditions where there is too much acid in the stomach. It is used to treat gastric and duodenal ulcers, erosive esophagitis, and gastroesophageal reflux disease (GERD). Omeprazole is a proton pump inhibitor that is used to treat symptoms of gastroesophageal reflux disease and other conditions caused by excess stomach acid. Omeprazole, sold under the brand names Prilosec and Losec among others, is a medication used in the treatment of gastroesophageal reflux disease (GERD), peptic ulcer disease, and Zollinger–Ellison syndrome. [1] Find patient medical information for Omeprazole (Prilosec, Prilosec OTC) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings.