Hydrocodone/oxycodone overdose Hydrocodone and oxycodone are opioids, medicines that are mostly used to treat moderate or severe pain. Hydrocodone and oxycodone overdose occurs when someone intentionally or accidentally takes too much medicine containing these ingredients. Opioid misuse is a worldwide problem and deaths from opioid overdose are numerous and increasing [1-5]. This topic review will discuss the mechanisms, clinical manifestations, and management of acute opioid toxicity. A summary table to facilitate emergency management is provided (table 1). Oxycodone overdose can be life threatening. Learn more about signs and symptoms of oxycodone overdose and how it can be treated. Naloxone is a drug that temporarily reverses the symptoms of opioid overdose, including changes in behavior and unresponsiveness and it normalizes breathing. Naloxone can save a person’s life until professional medical help arrives. This drug stops the effects of an opioid overdose by blocking the parts of the body that respond to opioids. Oxycodone (OxyContin) is a prescription opioid that can be lethal in high doses. Knowing the signs of overdose and the lethal dose of oxycodone can help prevent fatal outcomes. How Much Oxycodone Is Lethal? The lethal dose of oxycodone that can cause a fatal overdose varies significantly between individuals based on several factors, making it impossible and potentially dangerous to specify exact amounts. Oxycodone is a prescription pain medication for mild to severe pain. Learn about safe dosing, overdose risks, and warning signs to stay informed and protected. Opioid overdoses can be fatal if not treated quickly. Learn the signs, treatment options and how to respond in an emergency. Oxycodone is an opioid that can cause deaths related to overdoses. Learn more about the risks of an Oxycodone overdose here. Learn about oxycodone overdose symptoms; find out who is at risk for opioid overdose and how oxycodone overdose is treated.