Mood swings, cramps and irritability are just a few telltale clues that you're getting your period. Learn what you can do for PMS symptom relief. Presbyterian Medical Services is dedicated to strengthening the communities of New Mexico by providing accessible, advanced, and affordable health, education, and social services to people of all backgrounds. Our mission is to care for people, enrich lives, and empower families. Premenstrual syndrome (PMS) has a wide variety of signs and symptoms, including mood swings, tender breasts, food cravings, fatigue, irritability and depression. Premenstrual syndrome, or PMS, is a cluster of symptoms that usually show up each menstrual cycle a week or two before your period. About 80% of women report having at least one PMS symptom each. We collaborate with community groups, schools, hospitals and governments to improve community health because everyone should have access to the care they need. Learn more. Premenstrual syndrome, or PMS, describes physical and emotional symptoms that begin a week or two before your period. Most people who menstruate have at least one or more symptoms of PMS. PMS occurs more often in those who are in their late 20s and early 40s, have at least one child, have a family history of depression, and have a past medical history of either postpartum depression or a mood disorder.